PKA catalytic subunit mutations in adrenocortical Cushing’s adenoma impair association with the regulatory subunit
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چکیده
منابع مشابه
PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.
We recently identified a high prevalence of mutations affecting the catalytic (Cα) subunit of protein kinase A (PKA) in cortisol-secreting adrenocortical adenomas. The two identified mutations (Leu206Arg and Leu199_Cys200insTrp) are associated with increased PKA catalytic activity, but the underlying mechanisms are highly controversial. Here we utilize a combination of biochemical and optical a...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms6680